Chief & Presenting Author: Dr.Siddharam Janti

Co Author(s): Dr.Shinisha Paul Bravian, Dr.Raja A.M.

Abstract

We present a case of a 58-year-old male who developed defective vision and progressive whitish discoloration in the left eye following cataract surgery and topical moxifloxacin-dexamethasone use.
Clinical examination revealed total epithelial erosion, gritty white stromal deposits, and a positive corneal stain in the left eye. Corneal scraping ruled out fungal infection, confirming drug-induced keratopathy. Despite discontinuing moxifloxacin and initiating lubricants, therapeutic scraping was unsuccessful, leading to deep anterior lamellar keratoplasty.The mechanism of moxifloxacin-induced corneal toxicity involves corneal epithelial degradation, inhibition of collagen IV synthesis, and damage to Descemet's membrane and tight junctions. While moxifloxacin's safety is well-established, ophthalmologists should be vigilant for rare adverse effects like corneal toxicity, especially in postoperative patients.