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  5. FP0939 : Investigating Therapeutic Potential of Oral Vitamin B1,Mecobalamin and Vitamin D in Dry Eye Disease

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Chief & Presenting Author: Dr.Divya Katiyar

Co Author(s): Dr.Vikas Singh

Abstract

This prospective interventional study evaluates the effectiveness of systemic vitamin D and vitamin B12 supplementation in managing dry eye disease (DED). Participants with DED symptoms refractory to conventional treatment receive supplementation, while controls continue standard therapy. Outcome measures include OSDI score , TBUT and Schirmer’s test 1 over the study period.
The treatment group exhibited significantly greater improvements compared to the control group in both Schirmer's test and tear break-up time (TBUT). This suggests that systemic supplementation with vitamin D and vitamin B12 may effectively enhance tear production and stability, addressing key aspects of dry eye disease (DED) pathophysiology. These findings highlight the potential therapeutic benefit of oral vitamin supplementation in managing DED symptoms and improving ocular surface health. Further research is warranted to confirm these findings and establish optimal dosage and treatment duration.