Chief & Presenting Author: Dr. Sonali Prasad

Abstract

The purpose is to report the clinical course of patients with refractory neurotrophic corneal ulcers who were treated with standard treatment v/s topical insulin drops.
Methods: This is a prospective double-arm study of patients with neurotrophic corneal ulcers or epithelial defects refractory to standard medical and surgical treatment. Subjects were divided into groups A, Non-Insulin, and B-insulin. Insulin drops, prepared by mixing fast-acting insulin in artificial tears with a polyethene glycol and propylene glycol base at a concentration of 1 unit per millilitre, were prescribed four times daily.
Results: 48 patients- 30 group A, 18 group B. Complete re-epithelialization with the initial protocol = 80%. Duration of re-epithelisation = 7 to 45 days of treatment. group A 29+-11days, group B 18 +- 9 days.
Conclusion- Insulin was effective in treating NK at a faster rate, although the visual rehabilitation in both groups was insignificant