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  5. FP0902 : Optic Neuritis and Retinal Nerve Fiber Layer Dynamics: Insights from the North Indian Population

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Chief & Presenting Author: Dr. Mariyam Beg

Co Author(s): Dr.Santosh I Kumar

Abstract

Aim: This study aimed to assess retinal nerve fiber layer (RNFL) changes using spectral domain optical coherence tomography (SDOCT) in Indian patients with optic neuritis
Method:20 patients diagnosed with optic neuritis between three months to one year prior were assessed using SDOCT to measure RNFL thickness, comparing affected eyes with fellow unaffected eyes and normative database
Result: The average RNFL thickness in unilaterally affected eyes (80.77 ± 25.59 μm) was significantly reduced compared to unaffected eyes (97.92 ± 24.46 μm) (P = 0.031) and normative data (98 ± 1.0 μm) (P = 0.031). Bilaterally affected eyes had an average RNFL thickness of (67.71 ± 27.09 μm), significantly lower than the normative data (98.43 ± 0.76μm) (P < 0.001)
Conclusion: A significant reduction in RNFL thickness was observed in affected eyes compared to unaffected eyes and normative data. The most pronounced reduction was seen in the temporal quadrant, suggesting papillomacular bundle involvement