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  5. FP0087 : RETINAL STRUCTURAL AND MICROVASCULAR CHANGES BEFORE AND AFTER AMBLYOPIA THERAPY IN CHILDREN

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Chief & Presenting Author: Dr.MEGHNA SETHI

Co Author(s): Dr.Anju Rastogi, Dr.Kashish Garg, Dr.Umesh

Abstract

Study design: Prospective interventional study.

Purpose: To evaluate the differences in Central Macular Thickness (CMT), Retinal Nerve Fibre Layer (RNFL) thickness and Retinal Vascular Density (RVD) between pre and post-treatment amblyopic eyes.

Methods: Subjects aged 4-12 years with unilateral amblyopia underwent optical coherence tomography (OCT) and OCT-angiography (OCTA) before and after occlusion therapy for 3 months.

Results: The mean age of subjects was 9.27 ± 2.50 years. After amblyopia treatment, there was no significant improvement in BCVA of amblyopic eyes (p>0.05). However, the CMT and mean RNFL thickness decreased (p= 0.002 and p=0.011) and RVD values of SCP (p=0.047) and DCP (p=0.035) increased after amblyopia therapy.

Conclusion: The retinal structural and microvascular changes may precede the functional outcome of the treatment. Thus, OCT and OCTA can be used to correlate these changes with functional improvement in patients undergoing amblyopia therapy.