Chief & Presenting Author: Dr.Sunny

Co Author(s): Dr. Gogoi Rajendra Nath, Dr.Rajiv Das

Abstract

Study Design: Cross sectional study
Purpose:To investigate the histopathological changes of bulbar conjunctiva adjacent to Mooren's ulcer.
Methods: Using histochemical and immunohistochemical methods, specimens of bulbar conjunctiva from ten patients with active Mooren's ulcers who had conjunctival excision were examined to look into the expressions of cytokeratin in the conjunctiva.
Results : The conjunctiva showed neutrophil, plasma cell, lymphocyte, and eosinophil infiltration upon histochemical analysis.It was possible to see that the afflicted conjunctiva had an extensive infiltration of T cells and macrophages. The CD4 positive cells were the primary T lymphocytes that infiltrated. Comparing the CD4/CD8 ratio to normal bulbar conjunctiva, it was significantly greater. Conclusion : A large number of infiltrating macrophages are responsible for the immunopathological damage caused by infiltrating T lymphocytes, aberrant production of cytokines in Mooren's ulcer.