Chief & Presenting Author: Dr.Shivani Chaturvedi

Co Author(s): Prof. Dr.Sandeep Saxena

Abstract

Objective:To study spot urine albumin protein(SUAP)levels as biomarker for severity of diabetic retinopathy(DR).
Methods:Cross-sectional study investigated SUAP levels as biomarker for different stages of DR.104 cases, 40-65 years were categorized into 4 groups:controls,no diabetic retinopathy(NoDR),non-proliferative diabetic retinopathy(NPDR) and proliferative diabetic retinopathy(PDR).Spot urine test-done to evaluate albumin levels.Spectral domain optical coherence tomography(SD-OCT)(Carl Zeiss)was used to measure OCT-angiography-superficial and deep vessel density,foveal avascular zone,retinal nerve fibre layer and ganglion cell analysis.
Results:SUAP cut-off values were 106.0 and 189.50mg/day for NPDR and PDR respectively, served as biomarker on ROC curve analysis(AUC=0.653 and 1.000,p<0.001)for severity of DR.OCT parameters significantly correlated with severity of DR(p<0.001) and SUAP(p<0.001).
Conclusion:SUAP is biomarker for severity of DR correlating with OCT parameters.