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  5. FP0845 : Role of oral Pentoxifylline in Ethambutol induced Optic Neuropathy

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Chief & Presenting Author: Dr.Indu Yadav

Co Author(s): Dr.Indu Yadav , Dr.Perwez Khan, Prof. Dr.Mohan Shalini

Abstract

Study design:Prospective interventional study
Purpose:To assess the role of oral Pentoxifylline in Ethambutol induced optic neuropathy in patients undergoing ATT.
Methods:Total 30 patients who were diagnosed as ethambutol induced optic neuropathy were enrolled and Prospective interventional study was done
One group(n=15) were given oral Pentoxifylline(16-18/kg) and oral vitamin B complex for 6 months
Other(n=15) were given oral vitamin B complex for 6 months
Patients were followed monthly for 6 months
BCVA was taken using ETDRS chart
Contrast sensitivity using Pelli Robson contrast sensitivity chart
Colour vision by Ishihara chart Fundus examination
Visual evoked potential (VEP)
Result & conclusion:
Pentoxifylline has improved vision and contrast in ethambutol induced optic neuropathy, while there was no significant improvement in the other group.
There was no significant improvement in colour vision and VEP findings in both the groups.