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  5. FP0090 : Pro-re-nata regimen of autologous platelet-rich plasma injections for treatment of dry eyes

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Chief & Presenting Author: Dr.Anchal Tripathi

Co Author(s): Prof. Avinash Mishra, Dr.Atul Bhirud, Dr.Mohini Agrawal

Abstract

Purpose: To study the efficacy of platelet-rich plasma injections (PRPi) for treating dry eyes. Methods: Prospective, interventional study. One eye received PRPi, the other eye of the patient received a lubricating drop. Cases not improving at 1-month follow-up were reinjected with PRP. Outcomes were ocular surface disease index (OSDI), Schirmer’s test (ST), non-invasive tear breakup time (NIBUT), tear meniscus height (TMH), and ocular surface staining score (OSS) at baseline, 1-month, 3-months and 6-months follow-up (FU). Results: 60 out of 80 cases showed significant improvement in all the outcome measures at 1-month (p<0.001), when compared to controls; whereas 20 cases had underwent repeat injections. All the outcome parameters maintained a significant improvement at 6-months FU. Conclusion: PRPi, as a monotherapy given on pro-re-nata (PRN) basis, is a simple and efficacious modality of treatment in dry eyes; verified by improvement in subjective and objective tear-film parameters.